{"id":29719,"date":"2024-06-27T09:07:52","date_gmt":"2024-06-27T07:07:52","guid":{"rendered":"https:\/\/sysmatec.ch\/?post_type=product&#038;p=29719"},"modified":"2024-06-27T10:01:49","modified_gmt":"2024-06-27T08:01:49","slug":"multi-channel-bioreactor-rts-8-plus","status":"publish","type":"product","link":"https:\/\/sysmatec.ch\/en\/product\/multi-channel-bioreactor-rts-8-plus\/","title":{"rendered":"Multi-channel bioreactor RTS-8 Plus"},"content":{"rendered":"<p>It is a multi-channel bioreactor with non-invasive real time OD pH and pO2 measurement.<\/p>\n<p>The bioreactor utilizes patented Reverse-Spin\u00ae technology that applies non-invasive, mechanically driven, low energy consumption, innovative type of agitation where cell suspension is mixed by the single-use falcon bioreactor tube rotation around its axis with a change of direction of rotation motion resulting in highly efficient mixing and oxygenation for aerobic cultivation. Combined with a near-infrared, fluorescence and luminescence measurement systems, it is possible to register cell growth kinetics, pH and O<sub>2<\/sub>\u00a0non-invasively in real time. For pH and O<sub>2<\/sub>, innovative single-use sensor spots are used inside the tubes.<\/p>\n<p>Although O<sub>2<\/sub>\u00a0supply is one of the major issues in the cultivation of aerobic organisms, especially in oxygen limited conditions, adequate methods for real monitoring of dissolved oxygen were missing, and sufficient O<sub>2<\/sub>\u00a0supply was usually assumed. Innovative non-invasive oxygen sensors integrated in falcon tubes now enable online oxygen monitoring and give new insights into metabolic activities. The pH is one of the major issues in the cultivation of cells, yeast or bacteria. Cultivation vessels which are sensor limited are widely applied in academic and industrial bioprocess development. As adequate methods for real monitoring of pH were not available, cumbersome at-line sampling was used lacking high data density and interfering with growth. Non-invasive real time pH measurement provides new insights into metabolic activity and changes in metabolic pathways.<\/p>\n<h2>Description<\/h2>\n<ul>\n<li>Parallel cultivation of 8 tube bioreactors enables to save time and resources for bioprocess optimization<\/li>\n<li>Individually controlled bioreactor accelerates optimization process<\/li>\n<li>Possibility to cultivate microaerophilic and obligate anaerobic microorganisms (not strict anaerobic conditions)<\/li>\n<li>Reverse\u2013Spin\u00ae mixing principle enables non-invasive biomass measurement in real time<\/li>\n<li>Near-infrared optical system makes it possible to register cell growth kinetics<\/li>\n<li>Free of charge software for storage, demonstration and analysis of data in real time<\/li>\n<li>Compact design with low profile and small footprint for personal application<\/li>\n<li>Individual temperature control for bioprocess applications<\/li>\n<li>Active cooling for rapid temperature control, e.g. for temperature fluctuation experiments<\/li>\n<li>Task profiling for process automatization<\/li>\n<li>Cloud data storage to remotely monitor the process of cultivation while at home or using a mobile phone<\/li>\n<li>Non-invasive O<sub>2<\/sub>\u00a0and pH measurement allows for accurate monitoring of metabolic activities<\/li>\n<li>Real\u2013Time cell growth logging<\/li>\n<li>Real-Time pH and O<sub>2<\/sub>\u00a0measurement and logging<\/li>\n<li>3D graphical representation of OD or growth rate over time over unit<\/li>\n<li>Pause option<\/li>\n<li>Save\/Load option<\/li>\n<li>Report option: PDF and Excel<\/li>\n<li>Remote monitoring option (requires internet connection)<\/li>\n<li>Cycling\/Profiling options<\/li>\n<li>User manual calibration possibility for most cells<\/li>\n<\/ul>\n<h2>Applications<\/h2>\n<ul>\n<li>Fermentation real time growth kinetics<\/li>\n<li>Clone candidate screening<\/li>\n<li>Protein expression<\/li>\n<li>Temperature stress and fluctuation experiments<\/li>\n<li>Media screening and optimization<\/li>\n<li>Growth characterization<\/li>\n<li>Inhibition and toxicity tests<\/li>\n<li>Strain quality control<\/li>\n<li>Initial bioprocess optimization studies<\/li>\n<\/ul>\n<h2>Features<\/h2>\n<ul>\n<li>Light source Laser<\/li>\n<li>Measurement wavelength (\u03bb) 850 \u00b1 15 nm<\/li>\n<li>Measurement range 0-100 OD600<\/li>\n<li>E.coli factory calibration measurement range 0-50 OD600<\/li>\n<li>S.cerevisiae factory calibration measurement range 0-75 OD600<\/li>\n<li>Achievable user calibration measurement error (range 0.1-6 OD600) \u00b1 0.3<\/li>\n<li>Achievable user calibration measurement error (range 6-50 OD600) \u2264 5%<\/li>\n<li>Achievable user calibration measurement error (range 50-75 OD600) \u2264 10%<\/li>\n<li>Measurement periodicity per hour 1-60<\/li>\n<li>Temperature setting range +4\u00b0C &#8230; +60\u00b0C<\/li>\n<li>Temperature control range +15 \u00b0C below ambient &#8230; +60 \u00b0C<\/li>\n<li>Temperature stability \u00b10.3 \u00b0C<\/li>\n<li>Sample temperature accuracy (20\u00b0C \u2013 37\u00b0C) \u00b11 \u00b0C<\/li>\n<li>Tube sockets 8<\/li>\n<li>Sample working volume range 3\u201350 ml<\/li>\n<li>Speed control range 150\u20132700 rpm<\/li>\n<li>Reverse spin time setting range 150-250 rpm 0 s<\/li>\n<li>Reverse spin time setting range 250\u2013300 rpm 2-60 s<\/li>\n<li>Reverse spin time setting range 300\u20132700 rpm 0-60 s<\/li>\n<li>Display LCD<\/li>\n<li>Minimum PC requirements Intel\/AMD Processor, 1 GB RAM, Windows Vista\/7\/8\/8.1\/10\/11, USB 2.0 port<\/li>\n<li>Dimensions (W\u00d7D\u00d7H) 350 \u00d7 690 \u00d7 300 mm<\/li>\n<li>Weight 20 kg<\/li>\n<li>Nominal operating voltage AC 230 V, 50 Hz<\/li>\n<li>Power consumption 3.15 A \/ 500 W<\/li>\n<li>02 sensor yes<\/li>\n<li>Range 0-100%<\/li>\n<li>Accuracy \u00b10.05% O2 at 0.2% \/ \u00b10.4% O2 at 20.9%<\/li>\n<li>Drift &lt;0.03% O2 within 30 days<\/li>\n<li>Temperature range up to 40\u00b0C<\/li>\n<li>Response time (t90) &lt;6 s<\/li>\n<li>Storage stability 18 months<\/li>\n<li>pH sensor yes<\/li>\n<li>Range 4.0 &#8211; 8.5 pH<\/li>\n<li>Accuracy \u00b10.10 pH at pH 7<\/li>\n<li>Drift &lt;0.005 pH per day<\/li>\n<li>Temperature range up to 40\u00b0C<\/li>\n<li>Response time (t90) &lt;120 s<\/li>\n<li>Storage stability 18 months<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Laboratory multi-channel bioreactor with non-invasive real time OD pH and pO2 measurement.<\/p>\n","protected":false},"featured_media":29721,"template":"","meta":{"_crdt_document":""},"product_brand":[],"product_cat":[116],"product_tag":[],"class_list":{"0":"post-29719","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bioreactor","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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